Research brief
37human trials, ever

4,846 papers. 37 human trials.

The single most useful thing to know about this field.

What is known

Every record in Europe PMC whose title or abstract names cold atmospheric plasma or its variants: 4,846 papers. Of those, 459 were published in 2026 alone — about two a day. 33 are systematic reviews. 37 are controlled trials in living subjects, and two of those are veterinary. The strongest single result pools 12 randomised trials covering 477 patients in chronic wounds.

What is missing

Human evidence for almost everything else. Publication volume has grown roughly seventyfold since 2005. Published human trials have run at a steady two to four per year throughout.

What you can do with this

Say the number

It's startling, it's true, and it sounds like an attack on the category. That's why it gets believed.

Always give the denominator

“477 patients across twelve trials” is honest. “Hundreds of studies” is not.

Check it yourself

Europe PMC is free. Search the phrase restricted to title and abstract — and know that an unrestricted search returns 6,544, about a third of which are about blood plasma.

This is an extract. The full picture is in The Evidence Map — or start at the library index.

Cold Plasma Research Library. Compiled from Europe PMC and ClinicalTrials.gov, September 2026 — 4,846 cold plasma papers, 662 on plasma-activated water, 52 registered trials. Counts are title-restricted and therefore floors, not ceilings: a low number means barely anyone has made this their subject, not that nobody has ever looked.

These pages describe published research on a technology. They do not describe or endorse any product, they are not medical advice, and nothing here should be used to decide about treating a health condition. Speak to a qualified clinician about anything that matters.